Article

RegFM: an interpretable context-aware foundation model for human transcriptional regulation

2026-08-21

Abstract excerpt

Transcriptional regulation is governed by interactions between cis-regulatory elements (CREs) and trans-acting regulators in a context-specific manner. Although DNA and single-cell foundation models have enabled modeling regulatory biology at scale, most represent either sequence or cellular state alone, limiting their ability to capture context-dependent gene regulation. Here we present RegFM, a context-aware fou...

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Literature Corpus work: b9fb874a-7a62-5a86-84ff-92e4f3611864
DOI: 10.64898/2026.08.17.744355

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