Article

Mapping the Mutational Landscape for Streptokinase Binding to Plasminogen

2026-02-04

Abstract excerpt

Group A Streptococcus (GAS) expresses streptokinase (SK), a critical virulence factor that non-enzymatically activates the host’s plasminogen (PLG), to an active form, PLG SK , resulting in the degradation of fibrin clots and subsequent bacterial dissemination. PLG SK formation contrasts with the physiologic activation of PLG to the serine protease plasmin via a proteolytic mechanism. As a potent thrombolytic, S...

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Literature Corpus work: e843af78-727d-5a78-bd97-eedf38c25447
DOI: 10.64898/2026.02.04.703780

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