Article
M protein-mediated plasminogen binding is essential for the virulence of an invasive Streptococcus pyogenes isolate.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Aug 2008
Sanderson-Smith M L, Dinkla K, Cole J N, Cork A J, Maamary P G, McArthur J D, Chhatwal G S, Walker M J
Abstract excerpt
The human protease plasmin plays a crucial role in the capacity of the group A streptococcus (GAS; Streptococcus pyogenes) to initiate invasive disease. The GAS strain NS88.2 was isolated from a case of bacteremia from the Northern Territory of Australia, a region with high rates of GAS invasive disease. Mutagenesis of the NS88.2 plasminogen binding M protein Prp was undertaken to examine the contribution of...
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