Article

Investigating the Conformational Flexibility of Staphylokinase Across Multiple Time Scales

2026-02-06

Abstract excerpt

Cardiovascular diseases, including ischemic stroke, necessitate improved thrombolytic agents. A microbe-encoded plasminogen activator staphylokinase (SAK) is a promising alternative to the widely used tissue plasminogen activator (tPA) due to its high fibrin specificity and low production cost. To overcome potential immunogenicity hampering its use in clinical settings, the low-immunogenic variants SAK SY155 and S...

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Literature Corpus work: ca090e27-bb1a-5899-87b5-68d84bcc9162
DOI: 10.64898/2026.02.03.703606

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