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Article

Structural and functional basis of plasminogen activation by staphylokinase.

Thrombosis and haemostasis - 1 Apr 1999

Jespers L, Vanwetswinkel S, Lijnen H R, Van Herzeele N, Van Hoef B, Demarsin E, Collen D, De Maeyer M

Abstract excerpt

Staphylokinase (Sak), a 15.5-kDa bacterial protein, forms a complex with human plasmin, which in turn activates other plasminogen molecules to plasmin. Three recombinant DNA-based approaches, (i) site directed substitution with alanine, (ii) search for proximity relationships at the complex interface, and (iii) active-site accessibility to protease inhibitors have been used to deduce a coherent docking model of...

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PMID: 10235424

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural and functional basis of plasminogen activation by staphylokinase.PMID 10235424Read ↗

Staphylokinase Requires NH2-terminal Proteolysis for Plasminogen ActivationSemantic proximity Read ↗

Identification of a new exosite involved in catalytic turnover by the streptokinase-plasmin activator complex during human plasminogen activation.Semantic proximity Read ↗

Mutation of lysines in a plasminogen binding region of streptokinase identifies residues important for generating a functional activator complex.Semantic proximity Read ↗

Investigating the Conformational Flexibility of Staphylokinase Across Multiple Time ScalesSemantic proximity Read ↗

Role of the N-terminal region of staphylokinase (SAK): evidence for the participation of the N-terminal region of SAK in the enzyme-substrate complex formation.Semantic proximity Read ↗

Plasminogen substrate recognition by the streptokinase-plasminogen catalytic complex is facilitated by Arg253, Lys256, and Lys257 in the streptokinase beta-domain and kringle 5 of the substrate.Semantic proximity Read ↗

Mapping the Mutational Landscape for Streptokinase Binding to PlasminogenSemantic proximity Read ↗

Computational simulations assessment of mutations impact on streptokinase (SK) from a group G streptococci with enhanced activity - insights into the functional roles of structural dynamics flexibility of SK and stabilization of SK-μplasmin catalytic complex.Semantic proximity Read ↗

Role of the streptokinase alpha-domain in the interactions of streptokinase with plasminogen and plasmin.Semantic proximity Read ↗

The X-ray crystal structure of full-length human plasminogen.Semantic proximity Read ↗

Coevolutionary patterns in plasminogen activation.Semantic proximity Read ↗

The kringle domains of human plasminogen.Semantic proximity Read ↗

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