Article

Deep mutational scanning of the plasminogen activator inhibitor-1 functional landscape

2021-04-15

Abstract excerpt

<h4>ABSTRACT</h4> The serine protease inhibitor (SERPIN) plasminogen activator inhibitor-1 (PAI-1) is a key regulator of the fibrinolytic system, inhibiting the serine proteases tissue- and urokinase-type plasminogen activator (tPA and uPA, respectively). Missense variants may render PAI-1 non-functional through misfolding, leading to its turnover as a protease substrate, or to a more rapid transition to the late...

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Literature Corpus work: f9755a6d-0334-560a-95c4-847c3c2c86db
DOI: 10.1101/2021.04.15.440003

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