Article
Streptokinase variants from Streptococcus pyogenes isolates display altered plasminogen activation characteristics - implications for pathogenesis.
Molecular microbiology - 1 Dec 2012
Cook Simon M, Skora Amanda, Gillen Christine M, Walker Mark J, McArthur Jason D
Abstract excerpt
Streptococcus pyogenes (group A streptococcus, GAS) secretes streptokinase, a potent plasminogen activating protein. Among GAS isolates, streptokinase gene sequences (ska) are polymorphic and can be grouped into two distinct sequence clusters (termed cluster type-1 and cluster type-2) with cluster type-2 being further divided into sub-clusters type-2a and type-2b. In this study, far-UV circular dichroism...
Topics
- Amino Acid Sequence
- Animals
- Catalytic Domain
- Genetic Variation
- Humans
- Mice
- Mice, Transgenic
- Molecular Sequence Data
- Mutation
- Plasminogen
- Plasminogen Activators
- Sequence Analysis, DNA
- Streptococcal Infections
- Streptococcus pyogenes
- Streptokinase
- Virulence