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Article

Coevolutionary patterns in plasminogen activation.

Proceedings of the National Academy of Sciences of the United States of America - 5 Aug 2003

Gladysheva Inna P, Turner Ryan B, Sazonova Irina Y, Liu Lin, Reed Guy L

Abstract excerpt

The generation of plasmin by plasminogen (Pg) activators (PAs) is a physiologic process in animals that dissolves blood clots and promotes wound healing, blood vessel growth, and the migration of normal and cancerous cells. Pathogenic bacteria have evolved PAs [e.g., streptokinase (SK) and staphylokinase] that exploit the Pg system to infect animals. Animal PAs have a conserved ability to cleave a wide spectrum...

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Identifiers

PMID: 12878727
DOI: 10.1073/pnas.1631716100
PMCID: PMC170890

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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