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Article

Natural Selection and Evolution of Streptococcal Virulence Genes Involved in Tissue-Specific Adaptations

16 Dec 2003

Abstract excerpt

The molecular mechanisms underlying niche adaptation in bacteria are not fully understood. Primary infection by the pathogen group A streptococcus (GAS) takes place at either the throat or the skin of its human host, and GAS strains differ in tissue site preference. Many skin-tropic strains bind host plasminogen via the plasminogen-binding group A streptococcal M protein (PAM) present on the cell surface;...

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Identifiers

PMID: 14679231
DOI: 10.1128/jb.186.1.110-121.2004

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