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Article

Allelic variants of streptokinase from Streptococcus pyogenes display functional differences in plasminogen activation.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Sept 2008

McArthur Jason D, McKay Fiona C, Ramachandran Vidiya, Shyam Priya, Cork Amanda J, Sanderson-Smith Martina L, Cole Jason N, Ringdahl Ulrika, Sjöbring Ulf, Ranson Marie, Walker Mark J

Abstract excerpt

A common mammalian defense mechanism employed to prevent systemic dissemination of invasive bacteria involves occlusion of local microvasculature and encapsulation of bacteria within fibrin networks. Acquisition of plasmin activity at the bacterial cell surface circumvents this defense mechanism, allowing invasive disease initiation. To facilitate this process, S. pyogenes secretes streptokinase, a...

Topics

Enzyme Activation
Genetic Variation
Humans
Phylogeny
Plasminogen
Streptococcus pyogenes
Streptokinase

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 18511548
DOI: 10.1096/fj.08-109348

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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