Article

Biofunctional matrix models reveal mineral-dependent mechanoregulation of bone metastatic breast cancer

2022-07-02

Abstract excerpt

Bone metastasis is a leading cause of breast cancer-related deaths and often initiated by tumor cell dissemination to osteogenic niches. During new bone formation, osteoblasts first deposit osteoid, the collagen I-rich, unmineralized component of bone ECM, within which carbonated hydroxyapatite nanoparticles subsequently form. However, it remains elusive how bone matrix mineralization dictates tumor cell phenotype...

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Literature Corpus work: e83f36b3-ec45-5a63-85c6-c90af19c2b3a
DOI: 10.1101/2022.06.29.498001

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