Article

Bone mineral density affects tumor growth by shaping microenvironmental heterogeneity

2024-07-23

Abstract excerpt

<h4>ABSTRACT</h4> Breast cancer bone metastasis is the leading cause of mortality in patients with advanced breast cancer. Although decreased mineral density is a known risk factor for bone metastasis, the underlying mechanisms remain poorly understood because studying the isolated effect of bone mineral density on tumor heterogeneity is challenging with conventional approaches. Here, we investigate how bone mine...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 682dc6e9-3e02-5ea4-99e2-f9ff4d71f437
DOI: 10.1101/2024.07.19.604333

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Bone mineral density affects tumor growth by shaping microenvironmental heterogeneityDOI 10.1101/2024.07.19.604333Read

Biofunctional matrix models reveal mineral-dependent mechanoregulation of bone metastatic breast cancerSemantic proximity Read

Single-cell RNA sequencing reveals route-specific remodeling of the tumor microenvironment and identifies predictive factors of breast cancer metastasisSemantic proximity Read

Single-cell profiling of bone metastasis ecosystems from multiple cancer types reveals convergent and divergent mechanisms of bone colonizationSemantic proximity Read

Single cell heterogeneity and evolution of breast cancer bone metastasis and organoids reveals therapeutic targets for precision medicineSemantic proximity Read

ECM-remodeling perivascular stromal state associates with osteoclast functional state in breast cancer bone metastasisSemantic proximity Read

Complex mechanics of the heterogeneous extracellular matrix in cancerSemantic proximity Read

Shaping Up the Tumor Microenvironment With Cellular FibronectinSemantic proximity Read

Collagen Density Modulates the Immunosuppressive Functions of Tumor-Associated MacrophagesSemantic proximity Read

Unique macrophage phenotypes activated by BMP signaling in breast cancer bone metastases.Semantic proximity Read

The Matrisome: In Silico Definition and In Vivo Characterization by Proteomics of Normal and Tumor Extracellular MatricesSemantic proximity Read

Patient-derived scaffolds uncover breast cancer promoting properties of the microenvironmentSemantic proximity Read

Single-Cell RNA-seq Reveals Obesity-Induced Alterations in the Brca1-Mutated Mammary Gland MicroenvironmentSemantic proximity Read