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Biomarker-Driven Approaches to Bone Metastases: From Molecular Mechanisms to Clinical Applications

10 May 2025

Abstract excerpt

Bone metastases represent a critical complication in oncology, frequently indicating advanced malignancy and substantially reducing patient quality of life. This review provides a comprehensive analysis of the complex interactions between tumor cells and the bone microenvironment, emphasizing the relevance of the "seed and soil" hypothesis, the RANK/RANKL/OPG signaling axis, and Wnt signaling pathways that...

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PMID: 40426987
DOI: 10.3390/biomedicines13051160

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