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Article

Bone Endosteal Mimics Regulates Breast Cancer Development and Phenotype.

Biomacromolecules - 8 Apr 2024

Ben Ghedalia Peled Noa, Hoffman Dane K, Barsky Livnat, Zer Noy S, Amar Katya, Rapaport Hanna, Gheber Levi A, Zhang Xiang H-F, Vago Razi

Abstract excerpt

Bone is a frequent site for metastatic development in various cancer types, including breast cancer, with a grim prognosis due to the distinct bone environment. Despite considerable advances, our understanding of the underlying processes leading to bone metastasis progression remains elusive. Here, we applied a bioactive three-dimensional (3D) model capable of mimicking the endosteal bone microenvironment....

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Identifiers

PMID: 38499995
DOI: 10.1021/acs.biomac.3c01217

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