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Article

Unique macrophage phenotypes activated by BMP signaling in breast cancer bone metastases.

JCI insight - 9 Jan 2024

Ihle Claire L, Straign Desiree M, Canari Johana A, Torkko Kathleen C, Zolman Kathryn L, Smith Elizabeth E, Owens Philip

Abstract excerpt

Metastatic breast cancer (mBC) tissue in bone was systematically profiled to define the composition of the tumor microenvironment. Gene expression identified a high myeloid signature of patients with improved survival outcomes. Bone metastases were profiled by spatial proteomics to examine myeloid populations within the stroma that correlated with macrophage functions. Single-cell spatial analysis uncovered...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38193534
DOI: 10.1172/jci.insight.168517
PMCID: PMC10906463

Genes

BMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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