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A 3D-printed scaffold-based osteosarcoma model allows to investigate tumor phenotypes and pathogenesis in an in vitro bone-mimicking niche

25 May 2022

Abstract excerpt

The pronounced influence of extracellular matrix (ECM) on bone tumor progression and metastasis have gained increased attention, which is difficult to reflect in current in vitro methods including 2D cell culture and 3D tumor spheroids. Thus, novel osteosarcoma (OS) models are highly requested to recreate in vivo complexity of bone niche in an in vitro prototype. Herein a type of poly(L-lactide) scaffold-based OS...

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PMID: 35665234
DOI: 10.1016/j.mtbio.2022.100295

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