Article

Bioengineered human bone-mimetic niche compositions regulate breast cancer cell quiescence and therapy response

2025-12-22

Abstract excerpt

Disseminated tumor cells (DTCs) in the bone are widely regarded as the cellular seeds of late metastatic relapse in estrogen receptor-positive (ER+) breast cancer (BC). However, how distinct bone compartments influence BC cell quiescence and endocrine therapy response remains unclear. Mechanistic insight has been hindered by limited access to human bone samples and by the lack of relevant human models that permit...

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Literature Corpus work: 83ac48ce-3a7d-58ab-900e-01e8079f8cce
DOI: 10.64898/2025.12.18.695089

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