Article

Proteomics Identifies Osteomodulin as a Promoter of Breast Cancer Bone Metastasis via CDK1 Activation

2023-11-05

Abstract excerpt

<h4>Summary</h4> Metastasis to different organs remains the main cause of mortality in breast cancer. Molecular predictors of metastasis are limited as well as therapeutic options. Here, we conducted quantitative proteomics and phosphoproteomics analysis of patient-derived tumours, identifying osteomodulin (OMD) as a dysregulated protein and associated with bone metastases. Cancer-associated fibroblasts secrete O...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c3d0e962-1c96-54c9-bb18-677d006ab427
DOI: 10.1101/2023.11.03.565489

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Proteomics Identifies Osteomodulin as a Promoter of Breast Cancer Bone Metastasis via CDK1 ActivationDOI 10.1101/2023.11.03.565489Read

Cyclin D1 in Cancer: A Molecular Connection for Cell Cycle Control, Adhesion and Invasion in Tumor and StromaSemantic proximity Read

Development and validation of a novel bone metastasis-associated prognostic model for breast cancerSemantic proximity Read

Multidimensional analysis to elucidate the possible mechanism of bone metastasis in breast cancerSemantic proximity Read

In-Silico Multi-Omics Analysis of the Functional Significance of Calmodulin 1 in Multiple CancersSemantic proximity Read

Extracellular matrix signatures of human mammary carcinoma identify novel metastasis promotersSemantic proximity Read

Biofunctional matrix models reveal mineral-dependent mechanoregulation of bone metastatic breast cancerSemantic proximity Read

Breast cancer ovarian metastases show increased activity of GPCR pathwaysSemantic proximity Read

Unique macrophage phenotypes activated by BMP signaling in breast cancer bone metastases.Semantic proximity Read

Cytoskeleton remodeling induced by SMYD2 methyltransferase drives breast cancer metastasisSemantic proximity Read

Metastasis-related Plasma Membrane Proteins of Human Breast Cancer Cells Identified by Comparative Quantitative Mass SpectrometrySemantic proximity Read

A microprotein encoded by LINC00263 promotes breast cancer osteolytic bone metastasis by inducing osteoclastogenesis and inhibiting osteoclast ferroptosisSemantic proximity Read

A novel gene expression signature for bone metastasis in breast carcinomasSemantic proximity Read