Article

Single-cell Transcriptome Analysis Identifies Senescent Osteocytes as Contributors to Bone Destruction in Breast Cancer Metastasis

2024-03-14

Abstract excerpt

<title>Abstract</title> Breast cancer bone metastases increase fracture risk and are a major cause of morbidity and mortality among women. Upon colonization by tumor cells, the bone microenvironment undergoes profound reprogramming to support cancer progression that disrupts the balance between osteoclasts and osteoblasts, leading to bone lesions. Whether such reprogramming affects matrix-embedded osteocytes r...

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Literature Corpus work: d80c93b1-dd27-5992-91b0-6349a5c5df36
DOI: 10.21203/rs.3.rs-4047486/v1

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