Article

<i>Trpc6</i> gain-of-function disease mutation enhances phosphatidylserine exposure in murine platelets

2022-02-03

Abstract excerpt

Platelets enhance coagulation by exposing phosphatidylserine (PS) on their cell surface in response to strong agonist activation. Transient receptor potential channels, including TRPC6, have been implicated in the calcium influx central to this process. Here, we characterize the effect of a Trpc6 gain-of-function (GOF) disease-associated, and a dominant negative (DN), mutation on murine platelet activation. Plate...

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Literature Corpus work: e8380c0e-940f-5f73-a7ed-b79b4a03410d
DOI: 10.1101/2022.02.01.478727

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