Article
An EF hand mutation in Stim1 causes premature platelet activation and bleeding in mice.
The Journal of clinical investigation - 1 Nov 2007
Grosse Johannes, Braun Attila, Varga-Szabo David, Beyersdorf Niklas, Schneider Boris, Zeitlmann Lutz, Hanke Petra, Schropp Patricia, Mühlstedt Silke, Zorn Carolin, Huber Michael, Schmittwolf Carolin, Jagla Wolfgang, Yu Philipp, Kerkau Thomas, Schulze Harald, Nehls Michael, Nieswandt Bernhard
Abstract excerpt
Changes in cytoplasmic Ca2+ levels regulate a variety of fundamental cellular functions in virtually all cells. In nonexcitable cells, a major pathway of Ca2+ entry involves receptor-mediated depletion of intracellular Ca2+ stores followed by the activation of store-operated calcium channels in the plasma membrane. We have established a mouse line expressing an activating EF hand motif mutant of stromal...
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