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Article

TRPC6 Binds to and Activates Calpain, Independent of Its Channel Activity, and Regulates Podocyte Cytoskeleton, Cell Adhesion, and Motility

15 Aug 2019

Abstract excerpt

Significance Statement Mutations in the transient receptor potential channel 6 ( TRPC6 ) gene are associated with an inherited form of FSGS. Emerging evidence has linked TRPC6 activity with calpain activation and podocyte injury. In this study, the authors generated a TRPC6 knockout podocyte cell line from TRPC6 knockout mice, engineering these cells to express wild-type and various mutations of TRPC6. They show...

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PMID: 31416818
DOI: 10.1681/asn.2018070729

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