LRRC8 complexes are ATP release channels that regulate platelet activation and arterial thrombosis.

doi:10.1182/blood.2024026667

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LRRC8 complexes are ATP release channels that regulate platelet activation and arterial thrombosis.

Blood - 28 Aug 2025

Tranter John D, Mikami Ryan T, Kumar Ashutosh, Brown Gavriel, Abd El-Aziz Tarek Mohamed, Zhao Yonghui, Arullampalam Prakash, Ashworth Katrina, Jha Vishwanath, Abraham Nihil, Meyer Chloe, Ajanel Abigail, Xie Litao, Feng Yongmei, Hong Juan, Zhang Haixia, Kumari Tripti, Balutowski Adam, Liu Alice, Bark David, Nair Vinayak K, Lasky Nina M, Stitziel Nathan O, Lerner Daniel J, Campbell Robert A, Di Paola Jorge, Cho Jaehyung, Sah Rajan

Abstract excerpt

ABSTRACT: Platelet shape and volume changes are early mechanical events contributing to platelet activation and thrombosis. Here, we identify single-nucleotide polymorphisms in leucine-rich repeat-containing 8 (LRRC8) protein subunits that form the volume-regulated anion channel (VRAC), which are independently associated with altered mean platelet volume. LRRC8A is required for functional VRAC in megakaryocytes...

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PMID: 40540747
DOI: 10.1182/blood.2024026667
PMCID: PMC12755129

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