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Article

Pathophysiological consequences of receptor mistraffic: Tales from the platelet P2Y12 receptor.

Molecular and cellular endocrinology - 5 Jul 2017

Cunningham Margaret R, Aungraheeta Riyaad, Mundell Stuart J

Abstract excerpt

Genetic variations in G protein-coupled receptor (GPCR) genes can disrupt receptor function in a wide variety of human genetic diseases, including platelet bleeding disorders. Platelets are critical for haemostasis with inappropriate platelet activation leading to the development of arterial thrombosis, which can result in heart attack and stroke whilst decreased platelet activity is associated with an increased...

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Identifiers

PMID: 28212842
DOI: 10.1016/j.mce.2017.02.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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