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Article

R93W mutation in Orai1 causes impaired calcium influx in platelets.

Blood - 15 Jan 2009

Bergmeier Wolfgang, Oh-Hora Masatsugu, McCarl Christie-Ann, Roden R Claire, Bray Paul F, Feske Stefan

Abstract excerpt

The intracellular Ca(2+) concentration of many nonexcitable cells is regulated by calcium store release and store-operated calcium entry (SOCE). In platelets, STIM1 was recently identified as the main calcium sensor expressed in the endoplasmic reticulum. To evaluate the role of the SOC channel moiety, Orai1, in platelet SOCE, we generated mice expressing a mutated, inactive form of Orai1 in blood cells only...

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Source

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Identifiers

PMID: 18952890
DOI: 10.1182/blood-2008-08-174516
PMCID: PMC2628374

Genes

STIM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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