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Article

Trpc6 gain-of-function disease mutation enhances phosphatidylserine exposure in murine platelets.

PloS one - 1 Jan 2022

Boekell Kimber L, Brown Brittney J, Talbot Brianna E, Schlondorff Johannes S

Abstract excerpt

Platelets enhance coagulation by exposing phosphatidylserine (PS) on their cell surface in response to strong agonist activation. Transient receptor potential channels, including TRPC6, have been implicated in the calcium influx central to this process. Here, we characterize the effect of a Trpc6 gain-of-function (GOF) disease-associated, and a dominant negative (DN), mutation on murine platelet activation....

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Source

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Identifiers

PMID: 35749414
DOI: 10.1371/journal.pone.0270431
PMCID: PMC9231752

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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