Article

Combining mutation and recombination statistics to infer clonal families in antibody repertoires

2022-12-22

Abstract excerpt

B-cell repertoires are characterized by a diverse set of receptors of distinct specificities generated through two processes of somatic diversification: V(D)J recombination and somatic hypermutations. B cell clonal families stem from the same V(D)J recombination event, but differ in their hypermutations. Clonal families identification is key to understanding B-cell repertoire function, evolution and dynamics. We p...

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Literature Corpus work: fba347ea-fe83-5c7d-aea1-d19cdbcd6acb
DOI: 10.1101/2022.12.22.521661

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