Article

Investigating the impact of OCT transporter genotype on metformin-induced vitamin B12 deficiency

2016-01-01

Abstract excerpt

Metformin is the first-line therapy for the treatment of Type 2 Diabetes Mellitus (T2DM) and is the most widely prescribed anti-diabetic drug in the world. A common and potentially hazardous side-effect of metformin treatment is vitamin B12 deficiency. OCT1 (SLC22A1) and OCT2 (SLC22A2) are highly polymorphic drug transporters responsible for the hepatic and renal uptake of metformin, respectively. Studies have doc...

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Literature Corpus work: e7e63d26-aa10-5dd5-9379-141ed95a325b
DOI: 10.17638/03001170

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