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Article

Combinatorial Genetic Modeling of pfcrt-Mediated Drug Resistance Evolution in Plasmodium falciparum.

Molecular biology and evolution - 1 Jun 2016

Gabryszewski Stanislaw J, Modchang Charin, Musset Lise, Chookajorn Thanat, Fidock David A

Abstract excerpt

The emergence of drug resistance continuously threatens global control of infectious diseases, including malaria caused by the protozoan parasite Plasmodium falciparum A critical parasite determinant is the P. falciparum chloroquine resistance transporter (PfCRT), the primary mediator of chloroquine (CQ) resistance (CQR), and a pleiotropic modulator of susceptibility to several first-line artemisinin-based...

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Identifiers

PMID: 26908582
DOI: 10.1093/molbev/msw037
PMCID: PMC4868112

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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