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Article

Molecular Mechanisms of Drug Resistance in Plasmodium falciparum Malaria.

Annual review of microbiology - 8 Sept 2020

Wicht Kathryn J, Mok Sachel, Fidock David A

Abstract excerpt

Understanding and controlling the spread of antimalarial resistance, particularly to artemisinin and its partner drugs, is a top priority. Plasmodium falciparum parasites resistant to chloroquine, amodiaquine, or piperaquine harbor mutations in the P. falciparum chloroquine resistance transporter (PfCRT), a transporter resident on the digestive vacuole membrane that in its variant forms can transport these...

Topics

Antimalarials
Artemisinins
Chloroquine
Drug Resistance
Humans
Malaria, Falciparum
Membrane Transport Proteins
Mutation
Plasmodium falciparum
Protozoan Proteins
Quinolines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32905757
DOI: 10.1146/annurev-micro-020518-115546
PMCID: PMC8130186

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