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Article

Know your enemy: understanding the role of PfCRT in drug resistance could lead to new antimalarial tactics.

Cellular and molecular life sciences : CMLS - 1 Jun 2012

Summers Robert L, Nash Megan N, Martin Rowena E

Abstract excerpt

The prevention and treatment of malaria is heavily dependent on antimalarial drugs. However, beginning with the emergence of chloroquine (CQ)-resistant Plasmodium falciparum parasites 50 years ago, efforts to control the disease have been thwarted by failed or failing drugs. Mutations in the parasite's 'chloroquine resistance transporter' (PfCRT) are the primary cause of CQ resistance. Furthermore, changes in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 22286067
DOI: 10.1007/s00018-011-0906-0
PMCID: PMC11115045

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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