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Article

Quantitative genome re-sequencing defines multiple mutations conferring chloroquine resistance in rodent malaria.

BMC genomics - 21 Mar 2012

Kinga Modrzynska Katarzyna, Creasey Alison, Loewe Laurence, Cezard Timothee, Trindade Borges Sofia, Martinelli Axel, Rodrigues Louise, Cravo Pedro, Blaxter Mark, Carter Richard, Hunt Paul

Abstract excerpt

BACKGROUND: Drug resistance in the malaria parasite Plasmodium falciparum severely compromises the treatment and control of malaria. A knowledge of the critical mutations conferring resistance to particular drugs is important in understanding modes of drug action and mechanisms of resistances. They are required to design better therapies and limit drug resistance.A mutation in the gene (pfcrt) encoding a membrane...

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Identifiers

PMID: 22435897
DOI: 10.1186/1471-2164-13-106
PMCID: PMC3362770

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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