Article

Collateral hypersensitivity between ZY19489 and piperaquine neutralizes PfCRT-mediated drug efflux and Plasmodium falciparum resistance

2025-10-09

Abstract excerpt

<title>Abstract</title> <p>New antimalarial drugs are essential to combat the current emergence and spread of Plasmodium falciparum parasite resistance to first-line artemisinin-based combination therapies. Here, we identify a mechanism of parasite resistance to ZY19489, a triaminopyrimidine currently in a Phase IIb clinical trial. Low-grade resistance was mediated by a novel mutation in the P. falciparum chloroq...

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Literature Corpus work: 202b93af-f9f8-5e7a-9004-a9d27b037611
DOI: 10.21203/rs.3.rs-7697517/v1

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