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Article

PfCRT and its role in antimalarial drug resistance.

Trends in parasitology - 1 Nov 2012

Ecker Andrea, Lehane Adele M, Clain Jérôme, Fidock David A

Abstract excerpt

Plasmodium falciparum resistance to chloroquine, the former gold standard antimalarial drug, is mediated primarily by mutant forms of the chloroquine resistance transporter (PfCRT). These mutations impart upon PfCRT the ability to efflux chloroquine from the intracellular digestive vacuole, the site of drug action. Recent studies reveal that PfCRT variants can also affect parasite fitness, protect immature...

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Identifiers

PMID: 23020971
DOI: 10.1016/j.pt.2012.08.002
PMCID: PMC3478492

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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