Article
Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology.
PLoS pathogens - 1 Nov 2016
Gabryszewski Stanislaw J, Dhingra Satish K, Combrinck Jill M, Lewis Ian A, Callaghan Paul S, Hassett Matthew R, Siriwardana Amila, Henrich Philipp P, Lee Andrew H, Gnädig Nina F, Musset Lise, Llinás Manuel, Egan Timothy J, Roepe Paul D, Fidock David A
Abstract excerpt
Southeast Asia is an epicenter of multidrug-resistant Plasmodium falciparum strains. Selective pressures on the subcontinent have recurrently produced several allelic variants of parasite drug resistance genes, including the P. falciparum chloroquine resistance transporter (pfcrt). Despite significant reductions in the deployment of the 4-aminoquinoline drug chloroquine (CQ), which selected for the mutant pfcrt...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.