Article
Genetic and molecular basis of drug resistance and species-specific drug action in schistosome parasites.
Science (New York, N.Y.) - 13 Dec 2013
Valentim Claudia L L, Cioli Donato, Chevalier Frédéric D, Cao Xiaohang, Taylor Alexander B, Holloway Stephen P, Pica-Mattoccia Livia, Guidi Alessandra, Basso Annalisa, Tsai Isheng J, Berriman Matthew, Carvalho-Queiroz Claudia, Almeida Marcio, Aguilar Hector, Frantz Doug E, Hart P John, LoVerde Philip T, Anderson Timothy J C
Abstract excerpt
Oxamniquine resistance evolved in the human blood fluke (Schistosoma mansoni) in Brazil in the 1970s. We crossed parental parasites differing ~500-fold in drug response, determined drug sensitivity and marker segregation in clonally derived second-generation progeny, and identified a single quantitative trait locus (logarithm of odds = 31) on chromosome 6. A sulfotransferase was identified as the causative gene...
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