Article

Infection dose shapes granuloma phenotypes in a humanized mouse model of tuberculosis

2026-06-18

Abstract excerpt

<title>Abstract</title> <p> Tuberculosis (TB) remains a leading cause of infectious disease mortality worldwide, yet current murine models fail to fully recapitulate human granuloma biology. Here, we utilized hCD34 + NCG humanized mice (humouse) to investigate how infection dose shapes granuloma formation and disease progression following aerosol infection with <italic>Mtb</italic> CDC1551. Humouse were infect...

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Literature Corpus work: e79dd2f1-57e9-5036-94c4-8173c3bc0e77
DOI: 10.21203/rs.3.rs-9849520/v1

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