Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mouse models of human TB pathology: roles in the analysis of necrosis and the development of host-directed therapies.

Seminars in immunopathology - 1 Mar 2016

Kramnik Igor, Beamer Gillian

Abstract excerpt

A key aspect of TB pathogenesis that maintains Mycobacterium tuberculosis in the human population is the ability to cause necrosis in pulmonary lesions. As co-evolution shaped M . tuberculosis (M.tb) and human responses, the complete TB disease profile and lesion manifestation are not fully reproduced by any animal model. However, animal models are absolutely critical to understand how infection with virulent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antitubercular Agents
Share to Granuloma
Share to Host-Pathogen Interactions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mycobacterium tuberculosis

Share to Necrosis

Share to Neutrophils

Share to Receptors, Somatostatin

Share to Tuberculosis

Source

Open in PubMed Open full text

Identifiers

PMID: 26542392
DOI: 10.1007/s00281-015-0538-9
PMCID: PMC4779126

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mouse models of human TB pathology: roles in the analysis of necrosis and the development of host-directed therapies.PMID 26542392Read ↗

Mouse models for the genetic study of tuberculosis susceptibility.Semantic proximity Read ↗

The current state of animal models and genomic approaches towards identifying and validating molecular determinants ofMycobacterium tuberculosisinfection and tuberculosis diseaseSemantic proximity Read ↗

Aberrant macrophage activation and maladaptive lung repair promote tuberculosis progression uniquely in the lungSemantic proximity Read ↗

Drug testing in mouse models of tuberculosis and nontuberculous mycobacterial infections.Semantic proximity Read ↗

Mouse transcriptome reveals potential signatures of protection and pathogenesis in human tuberculosisSemantic proximity Read ↗

Infection dose shapes granuloma phenotypes in a humanized mouse model of tuberculosisSemantic proximity Read ↗

Spatial transcriptomic analysis of HIV and tuberculosis coinfection in a humanized mouse model reveals unique transcription patterns, immune responses and early morphological alterationsSemantic proximity Read ↗

A mouse model of tuberculosis reinfectionSemantic proximity Read ↗

Necrosis drives susceptibility to <i>Mycobacterium tuberculosis</i> in Polg <sup>D257A</sup> mutator miceSemantic proximity Read ↗

Perivascular and peribronchiolar granuloma-associated lymphoid tissue and B-cell gene expression pathways identify asymptomatic <i>Mycobacterium tuberculosis</i> lung infection in Diversity Outbred miceSemantic proximity Read ↗

Are mouse models of human mycobacterial diseases relevant? Genetics says: 'yes!'.Semantic proximity Read ↗

The C3HeB/FeJ Kramnik mouse as a model to investigate the efficacy of therapeutic tuberculosis interventionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.