Article

Aberrant macrophage activation and maladaptive lung repair promote tuberculosis progression uniquely in the lung

2023-10-20

Abstract excerpt

Pulmonary tuberculosis (PTB) represents 85% of the disease burden caused by Mycobacterium tuberculosis (Mtb) and promotes aerosol transmission infecting about a quarter of people globally. Most Mtb infections are effectively limited within primary granulomatous lesions. Containment failures lead to hematogenous spread and the formation of post-primary destructive PTB lesions. Factors that favor Mtb survival and r...

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Literature Corpus work: 36db8cba-0862-53fd-8ea3-b7bf594c410d
DOI: 10.1101/2023.10.17.562695

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