Article

Aggregation state of <i>Mycobacterium tuberculosis</i> impacts host immunity and augments pulmonary disease pathology

2021-05-19

Abstract excerpt

<h4>ABSTRACT</h4> Phagocytosis of Mycobacterium tuberculosis (Mtb) aggregates, rather than similar numbers of single bacilli, induces host macrophage death and favors bacterial growth. Here, we examined whether aggregation contributes to enhanced Mtb pathogenicity in vivo in rabbit lungs. Rabbits were exposed to infectious aerosols containing mainly Mtb-aggregates (Mtb-AG) or Mtb-single cells (Mtb-SC). The lung...

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Literature Corpus work: 590b4d2c-7430-5f1e-b305-938caf57034a
DOI: 10.1101/2021.05.19.444830

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