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Perivascular and peribronchiolar granuloma-associated lymphoid tissue and B-cell gene expression pathways identify asymptomatic <i>Mycobacterium tuberculosis</i> lung infection in Diversity Outbred mice

2023-07-31

Abstract excerpt

<h4>ABSTRACT</h4> Humans are highly genetically diverse, and most are resistant to Mycobacterium tuberculosis. However, lung tissue from genetically resistant humans is not readily available to identify potential mechanisms of resistance. To address this, we model M. tuberculosis infection in Diversity Outbred mice. Like humans, Diversity Outbred mice also exhibit genetically determined susceptibility to M. tu...

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Literature Corpus work
3083ed17-889b-52c8-a326-8772c1a06b7d
DOI
10.1101/2023.07.27.550843
Open publication

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Perivascular and peribronchiolar granuloma-associated lymphoid tissue and B-cell gene expression pathways identify asymptomatic <i>Mycobacterium tuberculosis</i> lung infection in Diversity Outbred miceDOI 10.1101/2023.07.27.550843
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