Back to search

Article

Single-cell transcriptomic profiling reveals a novel signature of necrotizing granulomatous lesions in the lungs of <i>Mycobacterium tuberculosis</i> -infected C3HeB/FeJ mice

2025-05-06

Abstract excerpt

Tuberculosis (TB) pathology involves complex immune responses within granulomatous lesions. Using single-cell RNA sequencing, we characterized the cellular compositions of necrotizing granulomatous lesions that developed in the lungs of Mycobacterium tuberculosis -infected C3HeB/FeJ mice. We identified 11 distinct major cell types, including phagocytes such as neutrophils and macrophages, and T cells, natural kil...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
72e248dd-d390-56d2-9c48-9da24f567e6b
DOI
10.1101/2025.05.06.652098
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Single-cell transcriptomic profiling reveals a novel signature of necrotizing granulomatous lesions in the lungs of <i>Mycobacterium tuberculosis</i> -infected C3HeB/FeJ miceDOI 10.1101/2025.05.06.652098
Paired single-cell and spatial transcriptional profiling reveals a central osteopontin macrophage response mediating tuberculous granuloma formationSemantic proximity
Early cellular mechanisms of type I interferon-driven susceptibility to tuberculosisSemantic proximity
Single-Cell and Spatial Transcriptomic Analyses Deciphering the Three-Layer Architecture of Human Tuberculosis GranulomasSemantic proximity
Spatial transcriptomic analysis of HIV and tuberculosis coinfection in a humanized mouse model reveals unique transcription patterns, immune responses and early morphological alterationsSemantic proximity
TREM2 <sup>+</sup> macrophages accumulate in alveoli of human pulmonary tuberculosis providing a permissive niche for bacterial growthSemantic proximity
Identification of SPP1-positive macrophages by single-cell spatial analysis in human lung tissues with mycobacterial infectionSemantic proximity
A multicenter spatial transcriptomics atlas of human tuberculosis and non-tuberculous mycobacterial diseaseSemantic proximity
Aberrant macrophage activation and maladaptive lung repair promote tuberculosis progression uniquely in the lungSemantic proximity
Perivascular and peribronchiolar granuloma-associated lymphoid tissue and B-cell gene expression pathways identify asymptomatic <i>Mycobacterium tuberculosis</i> lung infection in Diversity Outbred miceSemantic proximity
Morphoproteomics Identifies the Foamy Alveolar Macrophage as an M2 Phenotype with PD-L1 Expression in the Early Lesion of Post-Primary Tuberculosis: Implications for Host Immune Surveillance and Therapy.Semantic proximity
Immune Response to <i>Mycobacterium tuberculosis</i> and Identification of Molecular Markers of DiseaseSemantic proximity
Single Cell Analysis of Peripheral TB-Associated Granulomatous LymphadenitisSemantic proximity
Select a neighboring publication to make it the new centre.