Article

Soluble antigen arrays improve the efficacy and safety of peptide-based tolerogenic immunotherapy

2023-05-07

Abstract excerpt

<h4>ABSTRACT</h4> Autoantigen-specific immunotherapy using peptides offers a more targeted approach to treat autoimmune diseases, but the limited in vivo stability and uptake of peptides impedes clinical implementation. We previously showed that multivalent delivery of peptides as soluble antigen arrays (SAgAs) efficiently protects against spontaneous autoimmune diabetes in the non-obese diabetic (NOD) mouse mod...

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Literature Corpus work: e7809fce-c212-5292-8c81-c1b37b0e4dfc
DOI: 10.1101/2023.05.05.539161

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