Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Using gold nanoparticles for enhanced intradermal delivery of poorly soluble auto-antigenic peptides.

Nanomedicine : nanotechnology, biology, and medicine - 1 Feb 2021

Singh Ravinder K, Malosse Camille, Davies Joanne, Malissen Bernard, Kochba Efrat, Levin Yotam, Birchall James C, Coulman Sion A, Mous Jan, McAteer Martina A, Dayan Colin M, Henri Sandrine, Wong F Susan

Abstract excerpt

Ultra-small 1-2 nm gold nanoparticles (NP) were conjugated with a poorly-soluble peptide auto-antigen, associated with type 1 diabetes, to modify the peptide pharmacokinetics, following its intradermal delivery. Peptide distribution was characterized, in vivo, after delivery using either conventional intradermal injection or a hollow microneedle device. The poorly-soluble peptide was effectively presented in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens
Share to Dendritic Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Metal Nanoparticles

Share to Peptides

Share to Solubility

Share to T-Lymphocytes

Source

Identifiers

PMID: 33184020
DOI: 10.1016/j.nano.2020.102321

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Using gold nanoparticles for enhanced intradermal delivery of poorly soluble auto-antigenic peptides.PMID 33184020Read ↗

Single-cell RNAseq identifies clonally expanded antigen-specific T-cells following intradermal injection of gold nanoparticles loaded with diabetes autoantigen in humansSemantic proximity Read ↗

Soluble antigen arrays improve the efficacy and safety of peptide-based tolerogenic immunotherapySemantic proximity Read ↗

Microneedle-mediated vaccine delivery: harnessing cutaneous immunobiology to improve efficacy.Semantic proximity Read ↗

Immunomodulatory Dual-Sized Microparticle System Conditions Human Antigen Presenting Cells Into a Tolerogenic Phenotype In Vitro and Inhibits Type 1 Diabetes-Specific Autoreactive T Cell Responses.Semantic proximity Read ↗

Lipid-polymer hybrid nanoparticles utilize B cells and dendritic cells to elicit distinct antigen-specific CD4 <sup>+</sup> and CD8 <sup>+</sup> T cell responsesSemantic proximity Read ↗

Single domain antibody-antigen adducts that target Class II MHC induce antigen-specific toleranceSemantic proximity Read ↗

Comparing pooled peptides with intact protein for accessing cross-presentation pathways for protective CD8+ and CD4+ T cells.Semantic proximity Read ↗

Targeting the tumor-draining lymph node with adjuvanted nanoparticles reshapes the anti-tumor immune response.Semantic proximity Read ↗

Comparison of intradermal injection and epicutaneous laser microporation for antitumor vaccine delivery in a human skin explant modelSemantic proximity Read ↗

Enhanced presentation of MHC class Ia, Ib and class II-restricted peptides encapsulated in biodegradable nanoparticles: a promising strategy for tumor immunotherapy.Semantic proximity Read ↗

Size-Dependent Uptake of Particles by Pulmonary Antigen-Presenting Cell Populations and Trafficking to Regional Lymph NodesSemantic proximity Read ↗

This paper is the winner of an SFB Award in the Hospital Intern, Residency category: Peptide biomaterials raising adaptive immune responses in wound healing contexts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.