Article

Single-cell RNAseq identifies clonally expanded antigen-specific T-cells following intradermal injection of gold nanoparticles loaded with diabetes autoantigen in humans

2023-07-05

Abstract excerpt

<h4>ABSTRACT</h4> Gold nanoparticles (GNPs) have been used in the development of novel therapies as a way of delivery of both stimulatory and tolerogenic peptide cargoes. Here we report that intradermal injection of GNPs loaded with the proinsulin peptide C19-A3, in patients with type 1 diabetes, results in recruitment and retention of immune cells in the skin. These include large numbers of clonally expanded T-ce...

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Literature Corpus work: 933ed810-eccb-5f70-9309-666b3c504eb7
DOI: 10.1101/2023.07.05.23291245

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Single-cell RNAseq identifies clonally expanded antigen-specific T-cells following intradermal injection of gold nanoparticles loaded with diabetes autoantigen in humansDOI 10.1101/2023.07.05.23291245Read

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