Article

Covalent tumor anchoring spatially orchestrates antitumor immunity

2026-05-14

Abstract excerpt

<h4>ABSTRACT</h4> Protein immunotherapies can elicit potent tumor rejection, but reversible target engagement, incomplete tumor retention, and systemic leakage often erode spatial control. Here, we develop covalently anchored tumor immunotherapeutic proteins (CATIPs), a modular platform that uses proximity-enabled covalent chemistry to immobilize immune cues on tumor-cell surfaces after intratumoral administratio...

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Literature Corpus work: ca9ec0fe-9cb3-5ee7-a500-1dfc2161b9bf
DOI: 10.64898/2026.05.13.724746

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