Article

Synthetically mannosylated antigens induce antigen-specific humoral tolerance and reduce anti-drug antibody responses to immunogenic biologics

2023-04-07

Abstract excerpt

<h4>Summary</h4> Immunogenic biologics trigger an anti-drug antibody (ADA) response in patients, which reduces efficacy and increases adverse reactions. Our laboratory has previously shown that targeting protein antigen to the liver microenvironment can reduce antigen-specific T cell responses; herein, we present a strategy to increase delivery of otherwise immunogenic biologics to the liver via conjugation to a...

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Literature Corpus work: 0b3b92bb-def4-597a-98b6-068eac21501d
DOI: 10.1101/2023.04.07.534593

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