Article

Improving peptide vaccine manufacturability without sacrificing immunogenicity: substitution of methionine and cysteine with oxidation-resistant isosteres

2026-01-23

Abstract excerpt

<h4> A bstract </h4> Vaccines comprising peptide antigens for inducing T cell immunity are being developed for a broad range of therapeutic applications including prevention and treatment of cancer, autoimmunity, and infectious diseases. However, many peptide antigens contain cysteine and/or methionine, which are prone to form oxidation products that can present challenges to manufacturing and reduce biological...

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Literature Corpus work: 261bcdd0-f1a5-5039-a772-2847d29dd136
DOI: 10.64898/2026.01.20.699901

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