Article

Lamin A/C directs nucleosome-scale chromatin remodeling to define early lineage segregation in mammals

2026-01-02

Abstract excerpt

Chromatin organization underlies gene regulation and cell fate specification, yet how nucleosome-scale chromatin structure contributes to lineage segregation during early development remains unknown. Here, we resolved chromatin ultrastructure during the first lineage decision in mouse and human, which forms the pluripotent inner cell mass (ICM) and trophectoderm (TE). To achieve this, we developed dual-tilt chroma...

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Literature Corpus work: e77efd18-e084-59da-be3a-eb543d3f12d4
DOI: 10.64898/2026.01.01.696913

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