Article
Single-cell multiomics sequencing reveals the functional regulatory landscape of early embryos.
Nature communications - 23 Feb 2021
Wang Yang, Yuan Peng, Yan Zhiqiang, Yang Ming, Huo Ying, Nie Yanli, Zhu Xiaohui, Qiao Jie, Yan Liying
Abstract excerpt
Extensive epigenetic reprogramming occurs during preimplantation embryo development. However, it remains largely unclear how the drastic epigenetic reprogramming contributes to transcriptional regulatory network during this period. Here, we develop a single-cell multiomics sequencing technology (scNOMeRe-seq) that enables profiling of genome-wide chromatin accessibility, DNA methylation and RNA expression in the...
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